OP-GHK Cu

Product Description

Compound Identity

OP-GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper(II) Complex) is a tripeptide-metal coordination complex (3 amino acids; free peptide MW ≈ 340.4 Da; copper(II) complex MW ≈ 402.9 Da) first isolated through biochemical research conducted by Loren Pickart in the 1970s. The molecule consists of the tripeptide Gly-His-Lys coordinated to a copper(II) ion. It is intended strictly for laboratory and research purposes.

Receptor Selectivity & Binding Profile

OP-GHK-Cu does not act through a single defined receptor pathway. Its biological activity in research models is mediated through copper(II) coordination chemistry. The Gly-His-Lys sequence forms a square-planar copper(II) coordination complex with high binding affinity (Kd ~10^-15 M at physiological pH), characterized extensively in coordination chemistry literature.

Structural Features

Amino acid count: 3 residues (tripeptide: Gly-His-Lys)

Free peptide molecular weight: ~340.4 Da

Copper(II) complex molecular weight: ~402.9 Da

Coordination geometry: Square-planar Cu(II) chelate

Metal ion: Copper(II) (Cu²⁺)

Structural class: Tripeptide metal coordination complex

Areas of Active Scientific Investigation

Coordination Chemistry Research: Studies examining Cu(II) binding kinetics, coordination geometry, and complex stability constants.

Molecular Biology Research: Investigations into gene expression pathway modulation in cellular models.

Comparative Peptide Research: Studies examining OP-GHK-Cu alongside related copper-binding peptides and chelators.

Biochemistry Research: Academic research into cellular signaling pathways associated with tripeptide-copper coordination.

Regulatory & Research Context

Research-grade OP-GHK-Cu is sold strictly for in vitro research and laboratory use only. It is not intended for human or veterinary use, consumption, or application of any kind. It is not approved by the FDA to diagnose, treat, cure, or prevent any disease or condition. Not for use in any living organism.