MOTS C / 10 Vial

What is MOTS-c?

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a synthetic mitochondrial-derived peptide (16 amino acids; MW ≈ 2,174.5 Da) originally identified through academic research at the USC Leonard Davis School of Gerontology. It is encoded within the mitochondrial 12S ribosomal RNA region — one of the first peptides identified as encoded by the mitochondrial rather than nuclear genome. It is intended strictly for laboratory and research purposes.

Molecular & Structural Profile

MOTS-c is a small mitochondrial-derived peptide studied in cellular bioenergetics research for its role in mitochondrial signaling pathways. Its unique genomic origin within the mitochondrial 12S rRNA sequence distinguishes it structurally and biologically from nuclear-encoded peptides.

Areas of Active Scientific Investigation

Mitochondrial Biology Research: Studies examining mitochondrial signaling pathway dynamics and retrograde signaling in cellular models.

Metabolic Pathway Research: Investigations into AMPK signaling and cellular metabolic pathway regulation in vitro.

Comparative Peptide Studies: Research examining MOTS-c alongside other mitochondrial-derived peptides (MDPs).

Molecular Biology Research: Academic studies of mitochondrial genome peptide expression.

Regulatory & Research Context

MOTS-c is sold strictly for in vitro research and laboratory use only. It is not intended for human or veterinary use, consumption, or application of any kind. It is not approved by the FDA to diagnose, treat, cure, or prevent any disease or condition. Not for use in any living organism.

Scientific References

• Lee C, et al. Cell Metabolism. 2015.
• Kim KH, et al. Mitochondrion. 2017.
• PubMed: PMC4364747