What is 5-Amino-1MQ?
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a synthetic small molecule (not a peptide; MW ≈ 174.2 Da) developed through academic medicinal chemistry research. It is classified as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor. It is intended strictly for laboratory and research purposes.
Molecular & Structural Profile
5-Amino-1MQ is a quaternary ammonium compound based on the quinolinium scaffold, featuring an amino group at the 5-position and a methyl group at the nitrogen-1 position. Its mechanism of enzyme inhibition is characterized through competitive binding studies at the NNMT active site in biochemical assay models. As an NNMT inhibitor, it is studied in the context of NAD+ salvage pathway research and one-carbon metabolism in cellular biochemistry models.
Structural Features
Molecular weight: ~174.2 D
Structural class: Quaternary quinolinium small molecule
Molecular target: Nicotinamide N-methyltransferase (NNMT)
Inhibition mechanism: Competitive NNMT active site inhibitor
Pathway relevance: NAD+ salvage pathway / one-carbon metabolism research
Areas of Active Scientific Investigation
Enzyme Inhibition Research: Studies examining competitive inhibition kinetics at the NNMT active site, including IC₅₀ characterization and structure-activity relationship analysis in biochemical assays.
NAD+ Pathway Research: Investigations into NNMT inhibition effects on NAD+ precursor availability and salvage pathway flux in cellular models.
One-Carbon Metabolism Research: Studies examining SAM/SAH ratio dynamics associated with NNMT substrate competition in vitro.
Comparative Pharmacology: Research comparing 5-Amino-1MQ with other NNMT inhibitors and quinolinium scaffold variants in enzyme binding assays.
Regulatory & Research Context
5-Amino-1MQ is sold strictly for in vitro research and laboratory use only. It is not intended for human or veterinary use, consumption, or application of any kind. It is not approved by the FDA to diagnose, treat, cure, or prevent any disease or condition. Not for use in any living organism.
Scientific References
- Neelakantan H, et al. Biochemical Pharmacology. 2018; 147:56–65.
- Hong S, et al. Nature Communications. 2015; 6:8655.
- PubMed: PMC5226475 | PMC4598831
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