Compound Identity
OP-Kp10 is a synthetic decapeptide (10 amino acids; MW ≈ 1,302.5 Da) corresponding to the C-terminal 10-amino-acid sequence of the kisspeptin precursor protein. It is the shortest active fragment of the kisspeptin family retaining full receptor binding activity at the KISS1R/GPR54 receptor subtype.
Receptor Selectivity Profile
KISS1R / GPR54 (Kisspeptin Receptor) — full agonist activity; the primary and defining molecular target
No significant off-target receptor binding identified in comparative selectivity assays at pharmacological concentrations
Structural Features
Amino acid count: 10 residues (decapeptide)
Molecular weight: ~1,302.5 Da
Structural class: Linear kisspeptin C-terminal fragment
Receptor class: KISS1R / GPR54 agonist
Fragment origin: C-terminal 10 residues of kisspeptin-54 precursor
Areas of Active Scientific Investigation
Receptor Pharmacology Research: Studies examining KISS1R/GPR54 binding kinetics, agonist potency, and signaling pathway activation.
Comparative Peptide Studies: Research examining OP-Kp10 alongside longer kisspeptin variants (kisspeptin-13, -14, -54) in receptor selectivity profiling.
Neuroendocrine Research: Investigations into hypothalamic-pituitary signaling pathway activation in cellular models.
Molecular Biology Research: Academic studies of KISS1 gene expression and receptor regulation.
Regulatory & Research Context
OP-Kp10 is sold strictly for in vitro research and laboratory use only. It is not intended for human or veterinary use, consumption, or application of any kind. It is not approved by the FDA to diagnose, treat, cure, or prevent any disease or condition. Not for use in any living organism.
Scientific References
- Kotani M, et al. Journal of Biological Chemistry. 2001.
- de Roux N, et al. Proceedings of the National Academy of Sciences. 2003.
- PubMed: PMC3275728
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